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Floxsafe: No specific countermeasures after accidental overdose are recommended. In the event of overdose, symptomatic treatment should be implemented. ECG monitoring should be undertaken, because of the possibility of QT interval prolongation. Concomitant administration of charcoal with a dose of 400 mg oral moxifloxacin will reduce systemic availability of the drug by more than 80%. The use of charcoal early during absorption may be useful to prevent excessive increase in the systemic exposure to moxifloxacin in cases of oral overdose.
Floxsafe IV: Single doses up to 1200 mg and multiple doses of 600 mg over 10 days were administered to healthy subjects without any significant undesirable effects.
In the event of overdose, symptomatic treatment should be implemented including electrocardiogram (ECG) monitoring. The administration of activated charcoal after oral overdose may reduces systemic moxifloxacin exposure (approximately 20%), therefore the use of charcoal may be useful restrictively.
